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Site and Capabilities
Preparation of:
- Advanced intermediates
- Reference compounds (literature, competitor)
- Final targets
- Combinatorial building blocks
- Metabolites (putative or known)
- Resolution of enantiomers, chiral synthesis
- Natural products semi-synthesis
- Stable isotope labeled compounds
- Scaffolds (natural products or synthetic)
Specialized Equipment
- Molecular Distillation
- Fractional Distillation
- Hydrogenator ( 80-2000 psi)
- 2 liter glass Parr reactors
- 1.8 liter pressure reactors
- 22 liter pressure reactors
- Ozone Generator: up to 5 lb per day
- Biotage chromatography systems
- Analogix chromatography systems
- Proprietary chromatography systems (for large scale purifications)
- Preparative chiral separations (via third-party arrangements)
- Automated microwave synthesizer (parallel synthesis format)
On-Site Analytical Capabilities
- Multi-nuclei 300 MHz NMRs
- HPLC 1100
- Chiral HPLC method development
- FTIR
- GC
- HP LC-MS's
- Karl Fischer Titration Test
- Polarimeter
- Buchi Melting Point B-545
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